![]() These data provide the first evidence that we can improve on the rates of recurrence-free survival achieved by PD-1 blockade in resected high-risk melanoma. "The results of this randomized Phase 2b trial are exciting for the field. We look forward to advancing this program into the next phase of development." "Over the last six years, our teams have worked closely together combining our respective expertise in mRNA and immuno-oncology with a focus on improving outcomes for patients with cancer. Li, president, Merck Research Laboratories. "These positive findings represent an important milestone in our collaboration with Moderna," said Dr. We look forward to publishing the full data set and sharing the results at an upcoming oncology medical conference, as well as with health authorities." "We will begin additional studies in melanoma and other forms of cancer with the goal of bringing truly individualized cancer treatments to patients. mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma," said Stéphane Bancel, Moderna's Chief Executive Officer. "Today's results are highly encouraging for the field of cancer treatment. Adjuvant treatment with mRNA-4157/V940 in combination with KEYTRUDA reduced the risk of recurrence or death by 44% (HR=0.56 one-sided p-value=0.0266) compared with KEYTRUDA alone. (NASDAQ:MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, and Merck (NYSE:MRK), known as MSD outside of the United States and Canada, today announced that the Phase 2b KEYNOTE-942/mRNA-4157-P201 trial of mRNA-4157/V940, an investigational personalized mRNA cancer vaccine, in combination with KEYTRUDA ®, Merck's anti-PD-1 therapy, demonstrated a statistically significant and clinically meaningful improvement in the primary endpoint of recurrence-free survival (RFS) versus KEYTRUDA alone for the adjuvant treatment of patients with stage III/IV melanoma following complete resection. Results are the first demonstration of efficacy for an investigational mRNA cancer treatment in a randomized clinical trialĬompanies plan to discuss results with regulatory authorities and initiate a Phase 3 study in melanoma in 2023 and rapidly expand to additional tumor typesĬAMBRIDGE, MA and RAHWAY, NJ / ACCESSWIRE / Decem/ Moderna, Inc. MRNA-4157/V940, in combination with KEYTRUDA, demonstrated a statistically significant and clinically meaningful reduction in the risk of disease recurrence or death compared to KEYTRUDA monotherapy in stage III/IV melanoma patients with high risk of recurrence following complete resection
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She calls for Santa Rosa plums in her recipe, a similar plum that’s already had its season here in the Bay Area, but any red-fleshed plum like the Elephant Heart would work, or any plum or pluot that is not overly sweet (those that are both sweet and tart work best). I went with a recipe I had been waiting all year to try from Emily Luchetti’s A Passion for Ice Cream : a plum cornmeal cake paired with a plum sorbet. ![]() The plums hold up well in baking and develop an even richer, more robust flavor. Even a not-perfectly-ripened elephant heart plum is a thing of joy, but a perfect one is like the end of summer distilled into ambrosia.Īfter eating a couple of these little beauties, I actually had to make sure I didn’t get carried away and eat them all before I could bake anything with them (addictive, as in all the best fairy tales! or was that Persephone and her pomegranate seeds?) These plums are of course delightful out of hand, but also spectacular in many late summer or early autumn standards like galettes, tarts, or coffee cakes. Pick plums that are tender but not squishy soft or too firm either. Incidentally, the dustlike bloom you may see on them at the market is actually a good sign elephant heart plums are quite delicate and bruise easily, so seeing bloom means that have not been overhandled. I adore this plum, with its perfect heart shape and rich ruby color, the subtle complexities of its flavor such a contrast to its bolder, more straightforward cousins. Don’t resist the flesh is firm and burstingly juicy, the flavor sublimely sweet and tangy at once, redolent of honey and vanilla with tart berry undertones. ![]() If the slightly macabre name does not give you pause, the fruit’s appearance might: a rather mottled and dusty variegation of greens and purples, making one wonder if they’ve been pulled, half-ripened, out of a kitchen drawer, or, perhaps, if they are something rich and strange from the depths of some sun-dappled forest.Ĭut one open, and they indeed resemble something from a fairy tale: a jewellike, blood red interior that is softly, sweetly fragrant and begs to be bitten into, Snow-White style. I wanted to make something with plums before they disappeared, and this week when I went to market I saw a variety that I hadn’t baked with before: the oh-so-intriguingly named elephant heart plums. How fabulous is the bounty of fruit at the farmers’ markets right now? Check it out: this post is featured on Yumsugar and Serious Eats! The exploration of the cost of ambition, the impact of war, and the pursuit of knowledge is deftly woven into the storyline.įurthermore, the animation quality is consistently high throughout the series, ensuring that both action sequences and quieter moments are visually captivating. It prompts viewers to ponder ethical quandaries and societal issues while never losing sight of its engaging narrative. One of the aspects that truly shines is the way Fullmetal Alchemist: Brotherhood handles its themes without resorting to heavy-handedness. The overarching plot unfolds smoothly, weaving in political intrigue, ethical dilemmas, and moral gray areas that keep viewers questioning the boundaries between right and wrong. The pacing is excellently managed, avoiding unnecessary filler episodes. The series manages to strike a perfect balance between action-packed sequences and quieter, character-driven moments. The show adeptly delves into themes of sacrifice, redemption, and the consequences of one's actions. Their journey to restore their bodies after a failed alchemical experiment forms the emotional core of the series. ![]() The main protagonists, Edward and Alphonse Elric, are particularly well-crafted. Speaking of characters, Fullmetal Alchemist: Brotherhood presents a diverse cast, each with their own motivations, This balance allows for an engaging exploration of the characters' quests and struggles. The world's rules and mechanisms are well-defined, which immerses viewers without overwhelming them with information. The fictional universe is a harmonious fusion of magic and science, where alchemy is a powerful force. One of the series' greatest strengths lies in its meticulously constructed world. This review covers the entirety of the series without revealing specific plot details. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone-a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange.Īs Edward becomes an infamous alchemist and gains the nickname "Fullmetal," the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.įullmetal Alchemist: Brotherhood stands as an exemplar of exceptional anime storytelling that masterfully blends intricate world-building, compelling character development, and thought-provoking themes. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing "automail," a tough, versatile metal used in robots and combat armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. ![]() Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. |
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